Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer

Study Identifier
PCYC-0228
CT.gov Identifier
NCT00365183
EudraCT Identifier
Not available
EUCTIS ID
Not available
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844-663-3742 or [email protected]

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Study Details

Medical Condition
  • Lung Cancer - Non-Small Cell Lung Cancer (NSCLC)
    • Study Drug
  • Motexafin gadolinium and pemetrexed
    • Phase
    Phase 2
    Sex
    Female & Male
    Age
    18+ years
    Inclusion and Exclusion Criteria
    Inclusion Criteria:
    * 18 years or older * Stage IIIb, metastatic, or recurrent NSCLC patients who have received one prior platinum-based chemotherapy regimen * ECOG performance status score of 0 or 1
    Exclusion Criteria:
    * Laboratory values indicating inadequate function of bone marrow, liver, or kidneys * Symptomatic or uncontrolled brain metastases * Evidence of meningeal metastasis * \> 1 prior regimen (not counting adjuvant or neo-adjuvant cytotoxic chemotherapy if completed \> 12 months prior to regiment) * Medical condition that would increase risk if treated with motexafin gadolinium or impair ability to complete study procedures and assessments

    Protocol Summary

    The goals of this study are:

    • to determine if the combination of two drugs, motexafin gadolinium and pemetrexed, may be an effective treatment for patients with non-small cell lung cancer (NSCLC) who have had one previous chemotherapy regimen that included a platinum containing drug such as cisplatin or carboplatin.
    • to assess response to treatment in patients with NSCLC six months after beginning study treatment.

    Study Locations

    Location
    Status
    Location
    Huntington Beach, California, United States
    Status
    Not applicable
    Location
    Long Beach, California, United States
    Status
    Not applicable
    Location
    Chicago, Illinois, United States
    Status
    Not applicable
    Location
    Baltimore, Maryland, United States
    Status
    Not applicable
    Location
    Minneapolis, Minnesota, United States
    Status
    Not applicable
    Location
    St Louis, Missouri, United States
    Status
    Not applicable
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