Real Life Evaluation of Rheumatoid Arthritis Patients in Israel Treated With HUMIRA

1. Patient is eligible to Adalimumab treatment according to the Israeli National Health Basket and for whom a decision of initiating Adalimumab has already been taken. Patients that are naïve to Adalimumab therapy, that have been prescribed adalimumab in accordance to physician's clinical decision and according to local guidelines, up to 30 days prior to screening. 2. Patient has performed tuberculosis (TB) screening and treatment according to national guidelines for TB screening prior to anti Tumor Necrosis Factor (anti-TNF) treatment. 3. Patient has been diagnosed with Rheumatoid Arthritis (RA) and has disease duration \< 3 years. 4. Patient has moderately to severely active RA defined by Disease Activity Score (DAS) (moderately (3.2 ≤ DAS ≤ 5.1) severely (DAS ≥5.1)) 5. Patient is able to sign written informed consent. 6. Patient is treated with Methotrexate (MTX) alone or in combination with other Disease Modifying Antirheumatic Drugs (DMARDs) 7. Patient might have been treated with another anti-TNF inhibitor agent if discontinued due to secondary loss of efficacy or side effects.

1. Patient with known hypersensitivity to Adalimumab, or any of its components. 2. Patients suffering from serious infection, latent TB or other conditions prohibiting the use of Adalimumab. 3. Patient had previous non-response to an anti-TNF agent. 4. Patients currently treated with other biologic therapy.