A Study of Pain Relief in Low Back Pain

- Males and females, ages 21-75 years - If female, must be of non-child bearing potential or practicing birth control - Has a history of chronic low back pain for at least 6 months - Requires medication for the management of the chronic low back pain - Has sufficient pain to justify the use of around-the-clock opioids

- Is associated with any currently ongoing research study, or has previously participated in a Vicodin CR study - Is allergic or has had a serious reaction to hydrocodone, other opioids, or acetaminophen - Cannot discontinue pain medications, even for the short time prior to the study start - Has any clinically significant illness or recent injury, or has any significant laboratory abnormality, or has recently had major surgery, or plans to have surgery - Has a history of gastric bypass surgery or preexisting gastrointestinal narrowing, or history of diseases that may narrow the gastrointestinal tract - Has a history of malnutrition or starvation - Has a history of drug (licit or illicit) or alcohol abuse or addiction, or consumes more than 4 alcoholic drinks per day - Has a history of a major depressive episode within the past 2 years, or requires treatment with certain drugs for depression, or has a history of major psychiatric disorder - Is a pregnant or breastfeeding woman - Is incapacitated, bedridden, or confined to a wheelchair - Has initiated any new therapy or medication for chronic low back pain within 1 month of screening - Has had surgery, certain types of low back procedures, injured, or received certain medications for chronic low back pain within a certain specified time frame - Has back pain due to or associated with certain types of conditions - Has other conditions that may cause pain, such as rheumatoid arthritis, gout, or fibromyalgia