A Study Comparing the Analgesic Efficacy and Safety of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR)and Placebo in Subjects With Osteoarthritis

- Males or females ages 21 to 75 - Has osteoarthritis of the hip or knee - Requires therapeutic doses of medications for osteoarthritis - If female, must be of non-childbearing potential or practicing birth control - Has sufficient pain to justify the use of round-the-clock opioids

- Has received certain types of procedures or received certain medications for osteoarthritis within a specific timeframe - Has certain medical conditions which may interfere with pain assessments - Is allergic to or has a serious reaction to hydrocodone, other opioids, or acetaminophen - Has had certain infections, injuries or illnesses within the last month - Has had major abdominal surgery, certain diseases that may cause intestinal narrowing, or has a history of constipation, diarrhea or nausea and vomiting - Is receiving chemotherapy, or has been diagnosed with certain cancers within the past 5 years - Has a history of major psychiatric disorders or requires treatment with certain drugs for depression - Cannot discontinue pain medications, even for a short time, prior to the study start