Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye

* Male, 18 years of age or older, at the screening (day -51) visit OR * Females, who are naturally postmenopausal (permanent cessation of menstrual periods for at least 12 consecutive months) or are permanently sterilized (ie, eg, tubal occlusion, hysterectomy, bilateral salpingectomy, and/or bilateral oophorectomy) at the screening (day -51) visit * In at least 1 eye, all of the following objective measures of evaporative dry eye (EDE) must be present at the standardization (day -21) and baseline (day 1) visits. The same eye must qualify at both visits * Tear film break-up time (TBUT) ≥ 2 seconds and ≤ 7 seconds * Corneal sodium fluorescein staining score ≥ 1 and ≤ 4 (Oxford scheme) * Anesthetized Schirmer's tear test score ≥ 10 mm after 5 minutes * At the standardization (day -21) and baseline (day 1) visits, patients must have: * Ocular Surface Disease Index© (OSDI) score \> 12 (0 to 100 scale) * Overall ocular discomfort score ≥ 1 and \< 4 (0 to 4 scale; 0 = none, 4 = very severe) * Ocular burning score ≥ 1 and \< 4 (0 to 4 scale; 0 = none, 4 = very severe) * Blurred vision score ≥ 1 and \< 4 (0 to 4 scale; 0 = none, 4 = very severe) * In at least 1 eye, a lower lid margin meibum quality global assessment score ≥ 1 at the standardization (day -21) and baseline (day 1) visits. The same eye must qualify at both visits * In at least 1 eye, the number of lower lid margin expressible meibomian glands must be ≥ 3 at the standardization (day -21) and baseline (day 1) visits. The same eye must qualify at both visits * Use of an artificial tear product or lid hygiene (ie, warm compress, lid massage, lid scrub) for the treatment of dry eye disease, EDE or meibomian gland disease within 1 year of the standardization (day -21) visit

* Male patients with a history of, known, or suspected prostate cancer * Male patients with a prostate-specific antigen (PSA) level ≥ 4 μg/L * Female patients with a history of known or suspected breast, cervical, ovarian, or uterine cancer * Female patient who is of child-bearing potential * At standardization (day -21) and / or baseline (day 1) visits, a lower lid margin meibum quality global assessment score of non-expressible (NE) in either eye * Patients who are currently or have used hormone replacement therapy or estrogen and /or progesterone based products (including herbal and nutritional supplements) within 90 days of the standardization (day -21) visit or anticipated use during the study * Patients who are currently using or have used any androgen or anti-androgen treatment (including herbal and nutritional supplements), within 90 days of the standardization (day -21) visit or anticipated use during the study * Patients who are currently using or have used any hair growth product within 90 days of the standardization (day -21) visit or anticipated use during the study * Patients who are currently using or have used corticosteroids administered via any route within 30 days prior to the standardization (day -21) visit, or any anticipated use via any route of administration prior to the month 6 visit * Patients who are currently using or have used oral or topical macrolides, tetracycline, tetracycline derivative drugs (including doxycycline and minocycline), retinoids (eg, isotretinoin), or calcineurin inhibitors (ie, RESTASIS®, Ikervis®) within 60 days of the standardization (day -21) visit, or anticipated use prior to the month 6 visit